Author

Alice H. Lichtenstein, Lynne M. Ausman, Wanda Carrasco, Jennifer L. Jenner, Lisa J. Gualtieri,Barry R. Goldin, Jose M. Ordovas, Ernst J. Schaefer

Result

Plasma cholesterol concentrations declined after consumption of diets enriched in all the test oils; however, the declines were significantly greater for the canola (12%) and corn (13%) than for the olive (7%) oil-enriched diet Mean plasma LDL-C concentrations declined after consumption of diets enriched in all the test oils (16%, 17%, and 13% for canola, corn, and olive oil, respectively), and the magnitude of the declines was statistically indistinguishable among the test oils. Mean plasma high-density lipoprotein cholesterol (HDL-C) concentrations declined after consumption of the baseline diet, and these declines were significant for the canola (7%) and corn (9%) oil-enriched diets. Changes in LDL apolipoprotein (apo)B concentrations paralleled those of LDL-C. Switching from the baseline to the vegetable oil-enriched diets had no significant effect on plasma triglyceride, apoA-I, and lipoprotein(a) concentrations or the total cholesterol to HDL-C ratio. LDL apoB to apoA-I ratios were significantly reduced when the subjects consumed the vegetable oil-enriched diets. Differences similar to those observed in the fasting state were observed in the postprandial state. The major finding of this study is that significant reductions in LDL-C and apoB levels can be achieved in middle-aged and elderly women and men with initial LDL-C levels > 130 mg/dL by reducing dietary saturated fat and cholesterol intake and by incorporating vegetable oils rich in either monounsaturated fatty acids (canola and olive oil) or polyunsaturated fatty acids (corn oil) as part of an NCEP Step 2 diet Although differential effects were seen after the consumption of the three different oil enriched diets in some plasma lipid measures, none of these oils had a significant advantage in terms of altering the overall lipoprotein profile.

Conclusion

Total cholesterol and LDL cholesterol conc reduced in the participants who consumed canola oil

Author

 n1*, I-B Gustafsson2, S Basu1, J Nourooz-Zadeh3, C NaÈlseÂn1, A Turpeinen4, L Berglund1 and B Vessby

Result

The total cholesterol, LDL cholesterol and LDL=HDL ratio were lower after the RO (Rapeseed oil) diet compared to the SAT diet (P < 0.001), while HDL cholesterol and total triglyceride levels were similar after the two diets

Author

Jenkins, Philip W. Connelly, Benoît Lamarche, Patrick Couture, Penny M. Kris-Etherton, Sheila G. West, Xiaoran Liu, Jennifer A. Fleming, Roy R. Hantgan, Lawrence L. Rudel

Result

Diet modification, through the consumption of high oleic canola oil, led to the highest percentage of C18:1 CE in LDL particles, but did not increase LDL binding affinity to biglycan, measured using established methods. In contrast consumption of high oleic canola oil slightly decreased LDL-biglycan binding compared to baseline, as did corn/safflower oil consumption. These results indicate that enrichment of C18:1 in LDL CEs may result in a reduced residence time of LDL particles in the arterial wall, which could potentially decrease the development of atherosclerosis.

Conclusion

High oleic canola oil reduces the risk of atherosclerosis